In the Season 2 premiere, moments have passed since Murphy triggered the launch of tactical nuclear weapons and it's every man/woman for themselves as the group split up and try to outrun the impending blast. Meanwhile, Citizen Z finds himself battling thawed zombies and unable to communicate with the team, which leads him to make a desperate move that prompts the arrival of a mysterious and deadly bounty hunter.
The heroes are reunited, but soon find themselves navigating an unexpected tragedy as they engage in fierce fighting with both zombies and bounty hunters who are eager to capture Murphy, dead or alive. Meanwhile, Vasquez makes a strategic decision.
Murphy is finally tracked down; the Zs are attacked by superfast zombies known as Blasters; and they are introduced to an ultrapotent strain of marijuana called Z-Weed.
The survivors search for a "natural" cure for the virus at a greenhouse that's being guarded by zombie-plant hybrids.
Murphy's past comes back to bite him when a pregnant Serena tracks him down. Meanwhile, the survivors stumble upon a hidden Mennonite farm where the members are fighting for their lives against both zombies and anthrax.
Murphy's parental instincts kick in as he grows quite attached to Little Miss Murphy Jr., while the rest of the team can't help but wonder if there's more to this child than meets the eye.
A boating accident splits the group up as they are trying to cross the Mississippi; and 10K gets mixed up in Sketchy and Skeezy's latest scam, which leads to a frightening run-in with Escorpion.
Murphy is captured by an overly enthusiastic zombie fan who wants a new addition to his museum.
Mysterious things happen during a drive through RoZwell, N.M., where the team encounter bright lights in the sky and a beautiful but spacey woman who leads them on an adventure in search of zombie aliens.
The heroes are forced to split up when threatened by a massive horde of zombies. After going their separate ways, they meet two factions of a once united Native American tribe.
The heroes get mixed up in corporate politics after they seek refuge in a hotel that has been taken over by a group of white-collar survivors; and when someone tries to shoot Murphy, the search for the suspect turns into a game of Clue, but with zombies.
The team meets La Reina, Queen of the Zeros, after being captured; Dr. Kurian is ready for human trials on his Z-vaccine at the Zero compound.
All hell breaks loose when it's discovered that Dr. Kurian's Z-Vaccine doesn't work at all and anyone who has been inoculated is now susceptible to Murphy's unique brand of mind manipulation. Meanwhile, Warren tries to free Vasquez after he's sentenced to death by La Reina.
The heroes recall their pasts, including where they were when the Zombie Apocalypse started, as they finally reach their destination of California.
The heroes seem to be nearing the end of their adventure when, in the Season 2 finale, they drive through the abandoned city of Los Angeles on their way to the mobile CDC lab, where Dr. Merch awaits their arrival. Meanwhile, the Zeros are hot on Murphy and the gang's heels.