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Night one's main event pitting CM Punk against Roman Reigns and Seth Rollins in a triple-threat match, as the loyalties of managerial figure Paul Heyman are tested.

Elsewhere tonight, Jey Uso challenges Gunther for the World Heavyweight Title, aiming to become a world champion for the first time – against a man who has beaten him in several big matches already. Also, Tiffany Stratton defends her world title against Charlotte Flair (daughter of Ric), after the pair's feud has seen each woman go off-script in recent weeks.

And there are plenty of other big names involved tonight, including Rey Mysterio and LA Knight, before night two builds to a main event between the legendary John Cena (now a villain) and Undisputed Champion Cody Rhodes.

Night two's main event John Cena will challenge Cody Rhodes for the Undisputed WWE Championship. Cena is chasing a record-breaking 17th world title win, which would push him past Ric Flair according to WWE's count. Though he hasn't been seen onscreen since Elimination Chamber, expect an appearance from Dwayne "The Rock" Johnson, following up on his apparent alliance with Cena.

Another major title bout scheduled for tonight's show will pit Women's World Champion IYO SKY against former champs Bianca Belair and Rhea Ripley. Belair has yet to lose a match at WrestleMania. Will her streak be brought to an end long before it reaches the heights of The Undertaker's, or will Belair walk out as world champion for the fourth year in a row?

The WWE Intercontinental Championship is set to be defended in a Fatal Four-Way, featuring current champion Bron Breakker, recent signee Penta, and Judgment Day's Finn Balor and Dominik Mysterio. Speaking of Judgment Day, Liv Morgan and Raquel Rodriguez will put the WWE Women's Tag Team Championship on the line against Bayley and Lyra Valkyria. The latter two women qualified for the match by winning a gauntlet on a recent edition of "WWE SmackDown."

With Cena eclipsing Ric Flair's record of 16 World Titles, Orton is not far behind the new record, with 14 World Titles attached to The Apex Predator's resume. With an impressive 31 World Titles between these legendary Superstars, this match may have the most World Titles shared ever in a singles contest. 

In a heated rivalry born in betrayal, Women's Intercontinental Champion Lyra Valkyria will battle Becky Lynch for the title at WWE Backlash.

Former World Heavyweight Champion Gunther will battle Raw commentator Pat McAfee in what is sure to be a can't-miss matchup in St. Louis.

Jacob Fatu will defend his United States Championship against LA Knight, Damian Priest and Drew McIntyre at WWE Backlash.