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There is no Next Episode of Annedroids planned.
Eleven-year old genius and kid-scientist Anne has invented and built her own amazing androids. Nick discovers Anne's secret junkyard laboratory and enlists the help of Shania to befriend Anne and her mechanical companions. Together they help solve Anne's scientific problems through real-life solutions.
Anne is working out the kinks with newly made Pal, while Nick, Shania and the other androids play Hide and Seek. When Nick accidentally activates a security program that makes Hand, Eyes and Pal go into super-hiding mode, the kids have to find the missing androids before Pal's circuits overload.
Anne, Shania and the androids help Nick build a lawn-mowing robot to help him with his chores. All the while, Nick's Mom keeps stopping by the junkyard to check on their progress, nearly discovering Pal each time she comes by!
Hand feels left out when Anne would prefer to use Pal to help with an experiment; she thinks Anne likes Pal better. Nick devises the Android Games to show Hand what she's good at but the plan backfires when Eyes and Pal unexpectedly shine in the games.
Shania wants to form a garage band with her brothers but they're not very interested (or very good). Meanwhile at the junkyard, Anne and Nick work on upgrades to the security system. When they put Shania in charge of android-sitting, she finds out they have hidden musical talents and together they create a Garbage Band.
Eyes discovers a butterfly in the junkyard and wants to learn to fly, so Anne, Nick and Shania experiment with different ways to help Eyes off the ground. After several attempts with wings and helicopter blades, they discover that helium balloons are the best solution. That is, until the balloons lift Eyes over the junkyard fence and into the neighbor's yard.
Anne has built a brand new observatory and invites Nick and Shania to a sleepover so they can witness the lunar eclipse. First, Nick needs to get permission from his Mom to spend the night at the junkyard. The kids decide that it's time for Nick's Mom to meet Anne's Dad.
Shania is stuck at home taking care of her little brother Garth while Anne and Nick build a rainbow maker with a prism. Unfortunately, while Anne and Nick are busy, the prism accidentally sails over the junkyard fence when Hand and Eyes are playing monkey in the middle with Pal. The prism ends up in Garth's sticky hands. Hand throws Pal over the fence to retrieve it and Shania's got to help Pal get the prism back before anyone discovers the android in the house.
Anne experiments with growing plants but her crafty robo-mouse eats her experiment. Nick, Anne and Shania devise ways to catch the robo-mouse while the androids discover a stray cat in the junkyard. Hand, Eyes and Pal hilariously try to apply what Anne says about plant-care to taking care of the cat. But once Anne shows them that animals have different needs than plants, they take better care of the cat and want to keep her. Nick realizes the cat is the perfect solution to Anne's plant problem but, unfortunately, the stray has already moved on. Now the question is, will the cat come back?
Anne has recreated Nikola Tesla's plasma ball for her summer school project. Before they can get Anne's plasma ball up and running, the power goes out in the junkyard. Anne decides to try alternative types of energy (sun, wind and people power) to generate electricity for her Plasma Ball. Meanwhile, thanks to Shania's fixation on a popular singer, Hand develops an interest in the electric company truck that comes to fix the power lines... can androids feel love too?
Nick's best friend Zack comes over for a sleepover when Anne is in the middle of an experiment on magnetism. Nick tries to convince her to let Zack come help, but Anne doesn't want anyone else to know about the androids. However, when Pal accidentally gets turned into a magnet, Zack gets drawn across the street into the junkyard due to his metal backpack. Luckily, Zack is pivotal in demagnetizing Pal and becomes the newest member of their junkyard crew.
When Hand acts out of control, Anne, Nick and Shania wonder if it's possible she's throwing temper tantrums or if she's been infected by a computer virus. As they try to figure it out, Hand acts increasingly dangerous and Anne's Dad tells them to shut Hand down. Finally, the kids discover Hand wasn't out of control but was being manipulated by Shania's family's new remote control toy! Now the only question is, how can they get Hand back to normal?
Anne is thrilled when a meteorite lands nearby because the space rock is the last one she needs for her extensive rock collection. Fortunately, Eyes was tracking it in the sky and knows exactly where it landed. Nick convinces Anne to let Eyes come on their space rock adventure but, little does he know, other amateur geologists and Nick's Reporter Mom are on the meteorite hunt too!