Rip Hunter, Time Master, assembles a team of heroes and villains from the year 2016 to battle Vandal Savage, who has conquered Earth in the year 2166. To stop Vandal, they must travel throughout the villain's timeline and stop him from amassing enough power to become a world-conquering tyrant. First stop: 1975 and a meeting with the academic who knows the most about Vandal.
The team goes after Savage's operation in Norway in 1975, but the mission goes bad when Savage detonates the nuclear warhead he is trying to sell. Atom loses a piece of his suit's technology, and Martin contacts his younger self in 1975 in the hopes of finding it. Meanwhile, Carter and Kendra learn of a dagger that can kill Savage for good, but Kendra has to recall her first life in order to use it.
With Waverider undergoing repairs in 1975, Sara and Rip set out to check the bank where Vandal keeps his money. Meanwhile, Ray and Martin try to save Kendra's life, and Len, Mick, and Jax take a trip to Central City.
The team gets a lead on Vandal in 1986, and travels to Russia to discover what he's trying to create. While Len and Ray try to get close to the lead scientist, Rip entertains an offer from the Time Masters Council.
Rip sends Len and Sara in to rescue Martin, Ray, and Mick from the Russian gulag. However, he gives Sara secondary orders in case their rescue attempt fails. Meanwhile, Ray takes a beating for Mick, while Kendra helps Jax prove himself without becoming Firestorm.
The team finds itself stranded in Star City 2046, in a future where Vandal has conquered Earth and the city's defenders have fallen. Despite Rip's warnings, Sara sets out to find Oliver Queen and help him fight the city's ruler: Grant Wilson, the new Deathstroke.
While trying to pick up Vandal's trail, Waverider receives a distress signal from a sister ship. Rip goes to investigate, only to discover that time pirates have set a trap for him and his crew.
The team tracks Savage to a small town in Oregon during the 1950s. Upon arrival, they discover there have been a recent string of murders and they suspect Savage is involved.
Trapped in 1958 when Waverider leaves them behind, Ray and Kendra bond as a couple while Sara decides to return to the League of Assassins and Ra's al Ghul. Meanwhile, Chronos abducts Len and reveals his true identity.
The team convinces Rip not to kill Per Degaton, a boy who as an adult will help Vandal conquer the planet. However, Rip has other ideas and soon abducts the boy. Meanwhile, Kendra remembers more of her past with Carter, Ray meets an ancestor, and Sara tells Len to talk with the imprisoned Mick.
When the team needs a place to hide out, Rip sets a course for the Old West. Upon arrival, they start a fight with a gang of outlaws, putting the small town in jeopardy. Luckily, an old friend of Rip's, Jonah Hex, steps in to save them.
The Time Masters send their top assassin, The Pilgrim, back in time to kill the team's younger selves and eliminate them from the timestream. Once the team removes their past selves from the time stream, they are forced to take refuge in the place where Rip grew up.
The team goes after Vandal in 2146, and discover that he has a daughter. Meanwhile, Kendra discovers how she can kill Vandal but makes a startling discovery when she confronts the immortal tyrant.
The team attempts to return Vandal to the Vanishing Point for trial, after discovering that he has learned how to time travel and poses a threat to the timeline. However, the damaged Waverider may not be able to make the journey. Meanwhile, a captive Vandal attempts to turn the team against each other.
At the Vanishing Point, the Time Masters reveal the source of their power to Rip and how they've been manipulating the team... and why. Meanwhile, Mick is reprogrammed to serve as Chronos once more and hunt down Sara and Len, while Vandal travels to 2166 with Kendra to fulfill his destiny.
Rip returns his teammates to 2016 so that they can take up their original lives. However, they insist on completing their mission and the team soon begins hunting Vandal and his captives, Kendra and Carter.