Healin' Good♡Pretty Cure

Nodoka is still shaken by her last encounter with Daruizen which leaves her family and friends concerned for her when she starts acting distant. Meanwhile, King Byogen tasks Shindoine to search for Daruizen while Queen Teatine and her servants prepare to head to Earth. Rabirin approaches Nodoka later in the day and the latter confides in the Healing Animal of her guilt of abandoning Daruizen. Nodoka also explains that she does not want to go through her painful experience of falling ill again, even though it shaped her. Rabirin encourages Nodoka to release her true feelings. Following the encouragement, Nodoka decides not to help Daruizen to which Rabirin agrees, stating she was not responsible for Daruizen's need and was already doing her best, even in maintaining her own health. Just then, Rate falls ill due to Daruizen enhancing himself with multiple Mega Parts and attacking the town's lighthouse, forcing Nodoka and Asumi to assemble their friends. The four girls transform to engage an evolved Daruizen, during which, the TerraByogen viciously attacks Cure Grace while 'asking' her to help him again. However, Grace, having her resolve renewed, refuses him, finally standing up for herself. She proceeds to beat down Daruizen before her comrades join her to purify the Byogen general. However, Daruizen is not completely purified and is subsequently absorbed by King Byogen who further evolves himself into Neo King Byogen as a result. Despite the evil king's taunts, a fully motivated Cure Grace resolves to purify the king.

To the Cures' horror, Neo King Byogen uses his power to infect all of Sukoyaka City at once with the resulting infection also gradually spreading worldwide. Determined to restore the city by purifying the king, the Cures attempt to engage Neo King Byogen but discover he is protected by a barrier; he also effortlessly defeats them, causing them to lose their transformations. However, Queen Teatine arrives in time to help the Cures; using her powers along with her Healing Animal friends, she creates a barrier to contain Neo King Byogen and stop his infection temporarily, allowing the girls time to figure out how to defeat him. However, they are forced to flee when Shindoine attacks them, with Asumi using her wind powers to transport them outside Teatine's barrier. During their moment of respite, Asumi reveals she may have a way to counter Neo King Byogen's barrier: by using the Byogens' power along with their own, they should be able to pass through it. However in order to do so, Asumi must take in a Mega Part so she can use Byogen power. Despite initial protests, everyone agrees after seeing Asumi's resolve. Shindoine appears once again and the girls transform to fight her, hoping to get her remaining Mega Part, however Shindoine uses it to become stronger. After an arduous battle, the Cures manage to defeat Shindoine using Final Healin' Good Shower, restoring her to her original form, but Rate manages to tell them to use Healing Oasis to purify Shindoine further and allow Cure Earth to absorb her Byogen particle. Now with the ability to combat Neo King Byogen, the Cures prepare to face him.

The four Cures return to the forcefield's area to engage and purify Neo King Byogen. When they battle the king again, Asumi initiates her plan and her attack manages to break through the king's barrier. However, Neo King Byogen, having his full strength restored, breaks out of the Healing Animals' forcefield, absorbs the Cures, Queen Teatine, Rate and the three Healing Animals and uses all of his power to immediately infect the entire world. Inside the king, Nodoka and her friends are apparently defeated. Neo King Byogen taunts Nodoka again, but Nodoka resolves to keep fighting on to protect everyone from him, despite the insurmountable odds. Motivated by Nodoka's speech, the others trapped inside also resolve not to give up, as do the people of Sukoyaka City, the other Healing Animals and millions more people worldwide. Breaking free from the king, the four girls transform again to engage him once more. Despite Neo King Byogen's sheer power and relentless assaults, the four Cures manage to overpower him before purifying him with Final Healin' Good Shower, destroying the king once and for all. Following the battle, the townsfolk, having discovered the Cures' identities, agree among themselves to keep their discovery under wraps. Life goes on in Sukoyaka City with the people discreetly thanking the four girls, until Asumi and the Healing Animals announce to their friends of their departure from Earth. The Healing Garden residents leave their companions in a tearful farewell, but not before promising to remain friends.

Rabirin, Pegitan and Nyatoran reunite with their companions to take them to the Healing Garden for a visit. There, the three girls meet Asumi, Latte and Queen Teatine again; the queen thanks the girls for aiding them in protecting Earth against the Byogens. All three visitors befriend the other Garden residents, giving them some buns they brought along. However, they struggle to get along with a grumpy monkey resident who believes that humans are no better than the Byogens. As the four girls ponder over the monkey's words, a couple of MegaByogens spawn in, due to a wild NanoByogen which hid in the bun containers infecting the girls' buns. The girls transform to engage the MegaByogens but the monsters prove to be tough enemies with perfect cooperation among themselves. As the four Cures struggle to fight back, Rate summons a new Cure, Cure Summer, to the battle. With assistance from that new heroine, the four Cures manage to finally defeat the MegaByogen pack and purify the Fruit Spirit trapped in them. Afterwards, the three humans apologise for their carelessness but Queen Teatine assuages them, while Asumi reassures the monkey that humans can still fix the damages done to Earth. After leaving the Healing Garden, Nodoka, Chiyu and Hinata resolve to continue healing the world for their lifetime.