Coulson and his team track down an outbreak of Inhumans and discover that someone is killing or capturing many of them... and it's not who they think. Meanwhile, Fitz takes desperate steps to recover Jemma, and Daisy and Mack ask Lincoln for help.
The team turn to Asgardian Elliott Randolph for help deciphering the monolith and rescuring Jemma. Meanwhile, Grant abducts a key player in his quest to rebuild Hydra, while Lance begins his quest to find--and kill--Grant.
The ATCU launches a public alert to bring Lincoln in, and he reluctantly turns to Daisy for help when he realizes that he's in over his head. Meanwhile, Rosalind and Coulson negotiate a deal, and Lance and Melinda take the first step to infiltrating Hydra.
S.H.I.E.L.D. and the ATCU get a lead on the mysterious Inhuman killer, Lash. Meanwhile, Lance prepares for a face-to-face meeting with Grant, and Melinda turns to Coulson and Andrew for help.
Jemma tells Fitz how she survived on the alien planet for six and a half months... and who helped her.
While Melinda recruits Bobbi to help her find Werner after his attack on Andrew, Lance joins Daisy and Mack to confirm if Rosalind's man Banks is the mysterious Lash. Meanwhiile, Fitz and Jemma continue to try and bring Will home.
Melinda realizes who--and what--Andrew really is and confronts him. Meanwhile, Coulson has Daisy give Rosalind a tour of the Zephyr, and Lincoln reaches out to Mack for help.
Having gained Rosalind's trust, Coulson distracts her with a tour of the base while the rest of the team breaks into the ATCU headquarters to learn about the Inhumans they have captured and their attempts at a cure. Meanwhile,Grant learns the true secret of Hydra.
After Grant strikes at Coulson through someone close to him, Coulson swears revenge and goes after the only thing that Grant cares about. Meanwhile, Mack takes command of S.H.I.E.L.D., and Jemma and Fitz are captured during a reconaissance mission.
Mack and his team invade the Hydra castle in the hopes of bringing Fitz and Coulson back through the portal. Meanwhile, on the alien world Grant's team find Will and Fitz convinces him to lead them to the extraction point.
President Ellis sanctions Coulson to continue leading S.H.I.E.L.D. to deal with the Inhuman power. Meanwhile, Malick discovers that his new guest can speak, and Daisy's team encounters two new Inhumans in Bogota.
Coulson and a reluctant Talbot attend an international symposium on the Inhumans, and discover a traitor in their midst. Meanwhile, the team meets Talbot's new bodyguard, who may provide a vaccine against Terrigenesis.
A mission in Russia goes bad, and Bobbi and Lance are captured. To stop a coup and save S.H.I.E.L.D., the couple must make the ultimate sacrifice.
A group calling themselves the Watchdogs vows to take out any Inhumans that they can find. They begin their campaign of terror by taking out an ATCu facility, but the team soon learn that the Watchdogs are a front for Hydra.
Daisy tries to stop a future that she foresees due to an Inhuman's power. Meanwhile, Hive gives Gideon a taste of true power, and Giyera chooses sides.
Hive calls a meeting of Hydra's inner circle to show them his true face... and to teach Gideon a lesson in loyalty. Meanwhile, Daisy and Lincoln contact a former Afterlife resident who has information on Hive, while the others investigate Hydra's newest purchase.
Daisy's secret warriors rescue Coulson and his people from Hydra. However, when they return to base with a captive Gideon, Coulson realizes that there may be a traitor among them.
While Coulson, Melinda, and Lincoln try to recover Daisy, Fitz, Jemma, and Mack go after a scientist who may hold the key to stopping Hive.
Coulson sends a strike team to eliminate Hive before he poses a danger to the world. Meanwhile, Mack tries to save Daisy, and Lincoln insists on taking the anti-toxin that Fitz-Simmons has created to defeat Hive's parasites.
After the Accords are passed, Coulson brings Talbot to the S.H.I.E.L.D. base to take inventory of their Inhumans. Meanwhile, Daisy helps Lincoln escape while Holden discovers the process to create Inhuman Primitives.
S.H.I.E.L.D. manages to stop the missile launch and capture Hive... only to discover that he's exactly where he wants to be. Meanwhile, Daisy tries to deal with the guilt of what she's done.
One of the team will have to sacrifice themselves to stop Hive from spreading the pathogen across the world.