Season 3 begins with Masters and Johnson facing the press for the first time as they prepare to publish their study. As they do so, they recall last year's summer vacation when Bill was finishing work on their book, Virginia was facing parenting struggles, and Libby was pulling herself out from beneath a deep depression.
Masters takes on a high-profile patient; Virginia and Libby come to terms.
Masters and Johnson try to capitalize on their growing fame.
Masters tries to convince Johnson to rededicate herself to the study and to him; a familiar face returns to the clinic for help; Libby attempts to help Paul and Joy repair their shattered lives; Johnson fails to notice that Tessa is trying to make sense of her home life and the events at the homecoming dance.
Johnson's parents visit and insert themselves in the Johnson women's lives; Libby and Masters learn that Johnny has been bullied and try to fix the problem; Johnson finds unexpected excitement in the scent study; a promising fertility patient is found.
Masters and Johnson take on a celebrity couple who are looking to reinvigorate their sex life; Tessa comes to better understand her mother; Libby furthers her involvement in Joy's life but it comes with consequences that extend to Paul.
Masters and Johnson are interviewed when they take on an exotic new patient.
Johnson jets away with Dan Logan; Masters begins his surrogacy program.
Masters continues his surrogacy program, which is now under Johnson's critical eye.
Johnson objects to Masters' program, due to missteps in protocol.
Agendas collide as Masters, Johnson, Logan and his wife meet for dinner.
Season 3 ends with Masters and Johnson discovering that all of their hard work is now in jeopardy.