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The NFL kicks off the season in style as the defending Super Bowl champion Rams host the Bills. Buffalo is favored to dethrone Los Angeles in 2022 and win its first title behind quarterback Josh Allen. The Rams have won five straight season openers.

Tom Brady becomes the oldest starting quarterback in NFL history as his Buccaneers visit the Cowboys. The 45-year-old legend briefly retired during the offseason before deciding to return for a 23rd campaign. TB12 is 6-0 against Dallas all-time.

A rivalry as old as the NFL is renewed for the 2022 campaign as the Packers host the Bears. Green Bay has won six straight meetings with Chicago to take a 103-95-6 lead in the all-time series. Aaron Rodgers (GB) threw 16 TD passes in those wins.

The Bengals try to continue their recent mastery of the Ravens. Cincinnati won both meetings in 2021, scoring 41 points in each game. Running back J.K. Dobbins scored both of Baltimore's touchdowns in a 23-20 loss to Buffalo in Week 4.

Andy Reid's Chiefs host the Titans in a clash of division-leading clubs. Kansas City had a bye in Week 8. Reid, 20-3 in games he's coached after a regular-season break, tries to stop Tennessee's Derrick Henry, who rushed for 219 yards last week.

The 49ers (4-4) come off a bye week to host the Chargers (5-3). Los Angeles has won four of its past five outings following a three-point win at Atlanta in Week 9. Austin Ekeler (LAC) has 10 touchdowns this year. San Francisco is 2-1 at home in 2022.

The top AFC West teams collide as the first-place Chiefs (7-2) visit the Chargers (5-4). Kansas City rallied past Los Angeles 27-24 in Week 2. Chiefs rookie Jaylen Watson scored the go-ahead touchdown on a 99-yard interception return in that game.

The Patriots visit the Vikings for a Thanksgiving night affair. New England last played on the holiday in 2012, when it upended the New York Jets 49-19 in the Butt Fumble game. Minnesota is 6-2 on Thanksgiving after defeating Detroit 30-23 in 2017.

Aaron Rodgers and the Packers visit the City of Brotherly Love to play the Eagles. Rodgers is 5-2 against Philadelphia following a 30-16 victory in 2020. The 38-year-old has thrown 15 touchdown passes against three interceptions versus the Eagles.

The Buccaneers visit the Cardinals. Tampa Bay won the last meeting 30-27 in 2019. Arizona is 2-0 against the NFC South with victories over Carolina and New Orleans. Cardinals quarterback Kyler Murray accounted for four touchdowns in those games.

The Ravens host the Steelers for an AFC North matchup. J.K. Dobbins returned to the lineup and rushed for 120 yards and a TD in Baltimore's 16-14 win over Pittsburgh on Dec. 11. That decision snapped the Steelers' four-game head-to-head win streak.

From Lambeau Field.

A wild-card berth is at stake as the Packers (8-8) welcome the Lions (8-8) to Lambeau Field. Green Bay is in with a win. Detroit needs a victory, coupled with a Seattle loss to the Los Angeles Rams, to make the playoffs for the first time since 2016.