The Red Nose Day Special

Blake Shelton, Gwen Stefani, OneRepublic, Ellie Goulding, Steve Martin and the Steep Canyon Rangers, Sam Smith, James Taylor, Meghan Trainor and Adrienne Warren (the star of "Tina: The Tina Turner Musical") will perform.

In addition to the music performances, Jim Gaffigan, Tony Hale, Ray Romano and Lilly Singh will also showcase their comedic stylings. Film and TV favorites Bryan Cranston, Mario Lopez, Milo Ventimiglia and Noah Jupe will make appearances throughout the evening.

In addition to the unforgettable performances and original sketches, viewers will also see short compelling films that show how donations to Red Nose Day are used to change and save the lives of children in need in the U.S. and in some of the most underserved communities around the world.

In light of the health crisis and in an effort to help the public adhere to current health recommendations to avoid face-touching, Red Nose Day's iconic Red Noses will not be sold in Walgreens stores this year. Instead Red Nose Day and Walgreens teamed up to create this year's new digital Red Nose which offers an easy, fun way for the public to participate in the annual campaign, even while staying at home.

This year's event will raise money for those affected by Covid-19, particularly to support programs to ensure that children who are living in poverty are safe, healthy, educated and empowered.

This year's Comic Relief is set to be one of the best yet, with some star studded appearances from French and Saunders, Jack Whitehall, Tom Daley, Rose Ayling Ellis and Giovanni Pernice, David Walliams, Guz Khan, Matt Lucas, Jay Blades, and many more. Red Nose Day 2022 will be hosted by Alesha Dixon, David Tennant, Zoe Ball, Paddy McGuinness and Sir Lenny Henry. 

NBC will celebrate Red Nose Day's first decade in the U.S. with "Red Nose Day: Cheers to Ten Years.

The star-studded special will look back at the hilarious, inspirational and unforgettable moments of NBC's Red Nose Day programming and the life-changing impact of the campaign's first 10 years. 

The funniest skits from past Red Nose Days will be featured, including Coldplay's "Game of Thrones" the Musical, basketball with Paul Rudd & Blake Griffin, Kate McKinnon's "SNL" Weekend Update sketch and more.

A look back at the short film "Red Nose Day Actually," reuniting writer-director Richard Curtis and the cast of his beloved film "Love Actually" will also be featured.

The special will also include stories that highlight the impact of donations to Red Nose Day and how they help children across the U.S. and around the world.