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Lucky Flynn hasn't spoken to his family in years. When he learns that his mother has only days left to live, Lucky sets off in a hire car to drive the 4,000km from Sydney to Perth to say goodbye.

Lucky is desperate to see a doctor after losing his pills for his anxiety.

The two unlikely travel buddies experience a monumental coming-of-age moment as Meg experiences her first ever period. But after changing her tampon in a roadside toilet, she accidentally leaves her purse behind in the cubicle. Officially out of money, Lucky and Meg's day gets a whole lot worse when they run out of fuel as well, just as the local highway patrol is escalating its manhunt in the area for two highly wanted persons.

Waiting for their ute to be repaired, Meg and Lucky join a campground party on the Great Australian Bight, but the night takes a nasty turn when Lucky discovers a suicide note.

Lucky wakes up to find that Meg has taken off with the ute and the piano, leaving him all alone in the scorching Nullarbor heat. He contemplates giving up and going home, but a potentially poisonous snakebite causes him to have a vision of his mother, who urges him to find the piano and keep going.

Lucky transforms himself into a newly responsible, sensibly dressed man. Deciding his primary duty is to take care of Meg, he abandons his piano and moves on. But after facing some home truths and receiving more news about his mother, he is sent into a new spiral of despair.

After dropping Meg at her mother's house in Kalgoorlie, Lucky gets a phone call from Meg's father, worried sick about his daughter's whereabouts. Upon learning that Meg doesn't have a mother, Lucky frantically drives back to town to find her, but is intercepted by the police who arrest him for the theft of the horse-float.

Arriving at the Flynn family home in Perth, Lucky has a touching reunion with his mother, but his homecoming gets a much frostier reception from his brother Toby. Finally, the penny drops as to why it was so important to bring the piano all that way.