Ken is a cranky but lovable HMO doctor juggling medicine and parenting who realizes that even when he's right, his unorthodox approach is often wrong. Allison, his wife and a therapist, helps keep him in check while juggling responsibilities with their two kids -- Dave, their youngest, is always making things interesting with his quirky attitude, plus their teenage daughter, Molly, keeping them on their toes. Meanwhile at the clinic, Dr. Ken's staff includes his loyal, but oh-so-irritating staff, including a sharp tongued receptionist; a faithful nurse who is a confidante and partner-in-crime; a sweet, naive resident who's relentless optimism and quest for romance are a constant source of curiosity and irritation; and his nemesis, the hospital administrator, who never misses a chance to put the screws to Dr. Ken and his staff.
When the office celebrates a promotion for Clark, Ken is oblivious since he lives in his own world.. it's the last straw for Clark dealing with Ken's selfish ways. Clark writes a fake complaint comment card about Ken, so he's forced to attend a training seminar for better bedside manners, which leaves Allison at home to have dinner with Ken's parents.
Pat wants everyone to start working on Saturdays, so the workers in the office ask Ken to talk Pat out of it. When Ken visits Pat at home, he's shocked to find out he's living in a boat in the driveway. After Pat explains he's going through a divorce but still loves his wife, Ken thinks they've had a bonding moment. Meanwhile, Dave is given a new nickname at school and it brings up bad memories for Allison.
Ken meets Allison's ex, who's now a very well-regarded doctor, but when Ken has the chance to speak at a banquet in his honor, he treats it more like a roast. Meanwhile, Molly can't decide what she wants to be when she grows up for a school assignment.
Ken tries to make amends for botching his marriage proposal to Allison 20 years ago on Halloween. Meanwhile, Pat is accidentally drugged at the office by Damona and Julie, who decide to cash in on their boss's sudden generosity.
Molly admits to taking a sip of beer at a party, but insists she hated it and didn't drink the rest. While Allison is happy Molly is being honest with them, Ken is afraid of losing his little girl and uses the opportunity to explain to her what alcohol does to the body.. in medical terms. His experiment goes awry when he accidentally gets blitzed and makes a fool of himself in front of her friends.
Ken's sister Wendi (guest star Margaret Cho), a successful doctor/TV host on a medical talk show, comes to visit the family and tension ensues.. Ken can't admit that he's jealous of his sister's newfound success. So when Wendi invites Ken to be a guest on her show, he makes a mockery of it.
Molly rebels and gets a Japanese tattoo, which spirals Ken and Allison into having a cultural face-off when Allison claims she is more Japanese than Ken is Korean. At a holiday dinner, they push their traditional dishes on their guests, while Dave documents the Thanksgiving events for a school project. Also, Julie, fearful of being alone due to a recent heartbreak, invites the office over to her place - but Damona and Clark try finding a way to leave early so they can make it to their other Thanksgiving plans.
Ken's love of basketball hasn't rubbed off on Dave, who would rather attend a city council meeting about California's drought than play in a game. Meanwhile, Allison is skeptical of letting Molly dress more provocatively; and Damona schemes to get more vacation days.
When Allison gushes about how excited she is to go to Hawaii for the holidays, Ken realizes that he forgot to ask for those days off. So Ken, not wanting to admit he messed up, turns to lying, begging and bribing the master scheduler for the office (with whom no one has ever met), hoping he can give him the time off.
The Park family are in the airport on their way home from Hawaii when their flight is delayed for several hours. Ken has an interaction with Dr. Oz that goes awry - and then needs to get the famous TV doctor to switch airplane seats with him. Meanwhile, Allison gets overly involved in Molly's love life and accidentally breaks up with her boyfriend via text message, and Dave finds himself in a high-stakes card game with some college students. Back at Welltopia, it's "Black Monday," the clinic's busiest day of the year, and in Ken's absence, Julie is the doctor in charge, and Clark and Damona have to help her learn that thoroughness doesn't have to take forever.
Allison is upset to find out that Ken hasn't had a physical in years and urges him to do so. Ken asks Julie to sign that he's had a physical, but Julie insists on doing the real thing due to her professionalism. After the physical, Julie learns that Ken is suffering from moments of high stress - he blames Allison at first, but then they both realize it's due to their kids and their growing concerns. Meanwhile, Molly is having trouble holding down a job to earn money to go to skiing, but uses her entrepreneurial spirit to make the den's bathroom available to a nearby film crew - much to her parents' dismay.
After Ken's dad arrives for an impromptu stay, he starts taking on chores that Ken hasn't gotten around to doing -- like buying and installing a much needed new dishwasher, but then Ken purposefully breaks it. Meanwhile, Damona and Pat hook-up after a drunken night together. But instead of clinging to Damona the next day, Pat makes an announcement that takes Damona by complete surprise.
After Ken helps Dave in asking a girl he likes to go with him to the Valentine's Day dance, the plan quickly goes awry when Ken finds out that her dad (Joel McHale guest stars) is the well-known and rich malpractice lawyer whom he's had issues with in the past. Can these two "adults" put aside their dislike of each other for the good of their kids? Meanwhile, Julie changes her Valentine's Day party into a Presidents' Day party to cover up her rejection from Topher (Danny Pudi guest stars). So when Topher suddenly shows up, Damona and Clark provide their support.
Ken and the office staff are invited to a colleagues wedding, but things don't go as smoothly as they'd all like. Allison shows her dislike for weddings, but it turns out she just really doesn't like Ken's dancing - he's selfish on the floor. Meanwhile back at home, Molly hires someone to babysit Dave, but Dave wants to sneak out so he hires a friend to impersonate him.
Molly has a boyfriend, but Allison realizes he's the son of one of her patients, and has quite a moral dilemma when she learns, via a therapy session, that he might have been unfaithful. Meanwhile, Pat changes his demeanor with the staff as his evaluation approaches.
Ken feels that Molly is pulling away as a teenager and tries to reconnect by taking her and her friends to a concert for Emblem3 (guest starring/performing in the episode). Though she is embarrassed by her dad's antics at the concert, Molly does appreciate the effort and finally warms up to her dad -- just a little. Meanwhile, Allison takes Dave to a birthday party, but after he cuts his foot, he wreaks havoc on the Welltopia team when he is forced to face a big fear - a needle for the tetanus shot. Also, Damona struggles with how to break things off with Pat.
Ken tries to help a patient -- comic Dicky Wexler -- whose cancer has returned; Allison runs into a patient at another therapist's office.
Ken's confidence as a medical expert witness is shattered when the plaintiff's lawyer shreds his credibility on the stand; Dave gets Allison's help to sew a designer dress for Molly.
When Ken avoids giving Dave "the talk," Julie inadvertently does it herself. But then Ken has to fix things when Allison finds out that he took credit for doing it. Meanwhile, Clark takes questionable advice from Pat.
Ken, at the insistence of Allison, reluctantly joins a civics-minded community group - but it may not be what it seems.
A visit from Ken's college friend (guest star Jeff Ross as Doug), a touring stand-up comedian, ultimately spurs Ken to pursue his own lifelong dream of stand-up comedy. But when he does it, suddenly it's not as easy as he thought, nor does it go as he planned.