The night of the Aquaman premiere draws close and the crew is preparing themselves for the biggest event of Vince's career. Drama and Turtle keep finding better looking women to bring to the event, but they find themselves prematurely running out of passes to hand out to the hotties. Vince is less concerned about finding a date. He knows there's only one woman to bring -- his mom. Mrs. Chase is hesistant to make the trip to the West Coast due to a fear of travelling, but E finally convinces her to travel with both his and Turtle's mothers. Meanwhile, Ari adjusts to life in his new office (complete with broken down elevator) and finds that he's in for a huge challenge on his own.
It's Aquaman's opening day. Initial box office projections, already "Titanic"-sized, get even higher after the East Coast numbers stream in, giving everyone hope that the film has a chance to pass "Spider-Man" as the biggest opening weekend in history. To avoid getting recognized, Vince and the boys decide to take in a showing in the Valley, but the heat sets off blackouts and unsure West Coast numbers. The bouncing box office receipts and the heat push everyone to the brink, so to unwind, the crew ends up crashing a high school party, where Vince gets to live out his "Almost Famous" fantasy. When Ari finally finds them - a drunken Vince celebrating on a rooftop - he breaks the big news: "Aquaman" is back on track to break the weekend box office record.
After a night on the town celebrating Vince's movie star status with the success of "Aquaman" and the unveiling of the new Aquaman theme park ride, the crew gets a surprise visit from Dom, a recently paroled childhood friend from Queens. Back in the day, Dom took a rap for Vince, so Vince is glad to help out his friend in any way he can. But Dom's brash ways quickly prove to be too much for Eric, Drama and Turtle. Unfortunately for them, Vince hires Dom as his new head of security, so it looks as if he will be around for a while. Meanwhile, Ari has his hands full trying to keep his daughter away from a teen star with bad intentions.
With Aquaman packing multiplexes across the world, it's time for Vince to capitalize on his success and pick his next project. Ari informs Vince that the dream role of Pablo Escobar in "Medellin" is available, and all that he needs to do to land the role is to impress Phil Rubenstein, the film's producer. The entire entourage attends a party at Rubenstein's Santa Barbara mansion, but all of the goodwill that Vince earns is destroyed when a prized model of Shrek disappears from the producer's house during the party. Suspicion immediately turns to Dom, but the ex-con flatly denies the theft. Turtle, Drama and E don't believe him, but Vince does, and he won't waver in his support for his friend. "Medellin" is about to be totally derailed when Dom finally admits to lifting the doll during the party. The crew cut Dom loose and surreptitiously return the model, only to learn that there's a new complication: "Aquaman 2" has been approved and is scheduled to start shooting the same day as "Medellin."
Facing a scheduling conflict, Vince, Eric and Ari must figure out how to keep the 'Aquaman' sequel afloat without upsetting the Oscar(R)-winning director of 'Medellin.' When Saigon's song finally blows up, Turtle requests a sit-down with Ari.
It takes Vince to drag Drama away from the mob video game in which his image plays opposite Marlon Brandon as Don Corleone. The boys threesome plays hard to find as Vince refuses to dance to a major studio boss's tune as Ari avidly advised. Even a 12,500,000 offer for Aquaman 2 is ignored, Ari can't even get an audience without finding Drama a part first. Meanwhile the losers envy E an offer from his girl Sloan for a trio with Tori, which he believed a bluff but calling it makes it real.
Aquaman 2 is lost for good. Vince now volunteers to replace Zach Braff to be auctioned as dream-date for charity. Ari gets 12.5 million from Terence and sneakily starts spending it on upgrading his agency. Adam Davies gets wind of this and successfully demands a lucrative partnership. Eric's worrying about waking up spooned with the other trio girl makes it into a problem.
Vince may still get a break now that the studio is launching Queens Boulevard commercially, but he agrees with the director their re-cut is artistic murder. Johnny has an Edward Burns pilot audition, but throws a ridiculous tantrum, during which his car is stolen, so he isn't even on time. Now Terrance has signed Ari's settlement, he sets up his agency. As soon as Terrance finds out about the agency, he decides vindictively to stop payments and litigate regardless of cost. Just when people discover they won't be paid, probably for months, Terrance's ex offers Ari a way out.
Ari wants Vince to work on his image, but is seduced to follow the boys to Vegas, where 'infallible card player' Vince promises to win a fortune. Drama books his favorite masseur, former football star Ken, for 24 hours. Constant praise brings the stud to an unusual, alas wasted intimate move. Turtle manages to land the position of delegating the strippers contest judging, or in his mind 'the perks'.
Eric insults Ari, who therefore matches him with has-been super-producer Bob Ryan. Drama is driver for one day, as Turtle is supposed to sign his discovery's record contract with Sammy Kane. Alas, star Saigon doesn't show up. The boys track him down, only to face more problems. Meanwhile Vince enjoys a lazy day with his girl-friend, who has a sassy secret.
Ari nearly explodes as not only E, but also obnoxious Bob insists on coming along as he tries to sell their Ramone biopic project to a studio. Drama can't unwind for his first day on set as Ed Burns makes his part more challenging. The sting of the problem proves the solution. Meanwhile Turtle wants a pair of exclusive Fukijama sneakers, without standing in line early. Vince initially refuses to ask a celebrity favor, then accepts to do something special himself, in vain. Turtle gets a great surprise, the other boys an uppercut when Ari's trick to dump Bob backfires.
Vince goes shopping for a new agent with the gang. Ari tries to stop the Vince from getting that new agent.
The boys want to pay for Vince's birthday party as their gift, but Turtle's overspending maxes all their credit cards. Desperate to get Vince back as client from Amanda, Ari practically begs for a meeting and throws in the perfect gift - Vince's dream script, but a dead duck according to Amanda. Drama is obsessed with his Burns movie's billboard. Will Vince accept Turtle's way out, and reward Ari's bribery?
Ari's agency can sign up major gay star Jay Lester, but only if Lloyd uses his charms against his personal preferences. Vince wants a 'couples weekend' in Napa with E, Sloane and a new girl for himself. E worries Sloane won't get on with Lindsay, but the 'test' in L.A. ends up causing trouble. Meanwhile Drama and Turtle trust in their guard dog Arnold to get them weekend dates.
Now Ari acts all neurotic, having lost Vince as client, his wife drags him to yet another therapist, where he denies caring for any client. The boys realize they can't rally say no to Amanda just because she's too hot. After Ari admits being unable to fire blinded employee Rob Rubino, something he normally enjoys sadistically, his therapist recharges his mental energy. Amanda proposes her own surprising solution.
Vince accepted Amanda' proposal to defuse the sexual tension by doing it 'once', but they both enjoyed it too much to walk away, another business worry for Eric. When Drama hears his former friend Pauly Shore wants to punk him in the pilot of his new candid camera show, he eagerly accepts. Drama assumes boxer Chuck Liddell practically picking a fight is the gag, but to his horror is punk'd in a lame way, and Chuck swears physical revenge. When Ari's frat friend Scott Siegel visits, present a hot, young Jewish bride and announces he made $45,000,000 with stamps, jealousy strikes Ari and his wife.
In his battle with Vince's agent-lover Amanda, who seems to overplay her hand for Arthur Gatoff's 'Bogota' movie, Ari uses the pardon on Yom Kippur and ex-alcoholic Nicky Rubinstein's family. Alas Ari's wife refuses to let him break Sabbath restrictions to help out Nicky. It gets the boys doubt if she sabotages it to keep him in California and counter Ari, so E gets Vince to turn to Ari themselves. Meanwhile Vince has taken the boys to the race track and bets on King's ransom, which loses them one. Yet Drama decided to buy the stallion, although no stud but infertile, and an unruly troublemaker on his hands. There are surprising consequences on both fronts.
Drama is so nervous about the first airing of his TV series Five Towns that he can't stand to see any reviews. He finally bites the bullet after an hour of massage- it's murderous, even worse on himself. Vince and E tell Ari he doesn't get them back, they still want Medellin first. Ari arranges lunch with director Joe Roberts, whom the boys convince. But he demands Vince first makes Matterhorn. Instead, the boys decide to bid on the script and produce it themselves. Turtle has a hard time collecting d-Drama's old-timer from the haughty mechanic Rufus, but gets a date with bis daughter. The box office ends Drama's gloom.
Vince, Eric and Ari finally try to get "Medellin" off the ground. They meet with Yair and Nika Marx to get them to produce it. Problems evolve when Nika seems to be a little bit more interested in Vince than she should. Drama gets an offer from Brett Ratner to star in Rush Hour 3 (2007) and tells everyone about it, but when he meets with Ratner, it is revealed that Ratner made a mistake. Turtle meets with a girl whom he wants to spend the day with, but her father is very strict.
The boys move out of the dream-house after Vince refused to earn Medellin's $60,000,000 in bed. Ari finds a new financier, Nicky Rubinstein who just got access to his trust fund. Now they asks QB-director Billy Walsh, who prefers life as porn movie director 'Wally Balls', until he reads it's about Escobar. Alas he and Niucky hate each-other. E is prepared to compromise his relation with Sloan to be the producer. Meanwhile Drama was prepared to take a Spartan rental flat, but can hardly resist a condo way above budget.