While filming Medellin on location in Colombia, a documentary crew captures the behind-the-scenes action. Caught on film is tension between Billy and Eric, the pursuit of a beautiful actress and Drama's attempt to land a part in the film
Vince and the gang return from their Italian vacation. Billy is avoiding showing Eric and Vince the first cut of the movie. Drama volunteers his new condo for a welcome back party for Vince.
While Eric is trying to figure out how to fix Medellin, Billy submits it to Cannes, a move that will make it difficult for Vince to find work if it is rejected. Drama has a date with a woman he has desired for years, and brings Turtle along for her friend, who turns out to be an older woman. While he reluctantly agrees to continue on with the date, it's Drama who ends up with her. Vince finds himself at Dennis Hopper's house where he bets on a soccer match, with money he doesn't have.
Eric has to tell Harvey that he doesn't own Medellin and will be going to Cannes. Drama must take the Beverly Hills mayor out on the town so he can be annexed into that area.
When Billy accuses Eric of leaking the Medellin trailer on YouTube, their already strained relationship goes from bad to worse. Meanwhile, Ari lines up Vince's next dream project, and Drama will go to any lengths to buy a hat.
Ari must convince Lloyd to come back to work after Lloyd has a nasty breakup with Tom, Turtle's shady cousin makes them an offer they cant refuse.
Capitalizing on a romance-related bet with E and Vince on who can score with the ladies first, Drama takes Turtle under his wing to the one place where love knows no boundaries: Craigslist.
While E gets a new office and tries to announce his position as Vince's manager, Vince and Turtle fight with Gary Busey over an antique desk with a rich Hollywood history.
Eric gets into a car accident with Anna Faris. After she gives him his number so he could call for her insurance, he tries to contact her, but finds out she gave him a wrong number. So, he uses a star map to look up her address and goes to her house to talk to her. When they meet, they get along well and Eric actually drives Anna to a meeting for a movie. Meanwhile, Turtle is desperate because the boys ran out of weed, and while getting new drugs, Turtle, accompanied by some girls, gets stopped by the police.
While Vince is determining whether or not he wants to do Billy Walsh's next project as a personal favor, E takes on Anna Faris as a new client.
Vince and co. are headed to Cannes for the premiere of the Medellin, but it's complicated when LAX is shut down due to a terror alert scare.
The boys are in Cannes trying to seal the deal on Meddellin with big studio before the screening, while Yair Marx tries to buy them out with loads of cash. Meanwhile Johnny Drama finds his "true love".