Murdoch finds himself an amnesiac in Britain with professional killers trying to find out what he knows about a planned assassination.
Murdoch is assigned to an adjacent station house when one of their officers is found murdered in Toronto's Chinatown. His theories on the crime come under question.
Detective Murdoch enters the secretive world of the Freemasons when a new member is poisoned during his initiation ceremony. Things take a strange turn when Doctor Ogden reveals to Murdoch, Crabtree and Inspector Brackenreid that the young accountant really wasn't the man everyone thought.
Tragedy strikes close to home when Brackenreid's son Bobby suddenly disappears while playing with a friend on a sunny afternoon.
A clearly disturbed young woman possessed of four personalities takes an ax to her abusive father possibly because of a trauma suffered seventeen years earlier.
When a famous Rembrandt nude is stolen while it is in transit on a moving elevator, Murdoch, who was present during the theft, finds himself asking how, not who.
When a traveling circus comes to town, a series of murders, starting with the beautiful tiger trainer, take center ring with Murdoch and Brackenreid.
When Murdoch finds himself invited to a meeting of the local eugenics society, which is committed to research on genetic engineering, a dog shows up with a severed arm.
Two murdered but well-preserved bodies are found after a shed is torn down, and it's discovered that one of them had fought in the War of 1812.
Murdoch investigates the suicides of heirs to a great manor house and family fortune, but evidence begins to mount that it might be murder.
Detective Murdoch investigates a bizarre case when a convicted murderer apparently manages to survive the hangman's noose.
A model who poses for naughty postcard photos but moonlights as a prostitute is found strangled in the park. It is discovered that she was blackmailing her clients.
When Murdoch discovers that a victim has been cooked, he enlists the aid of Nicholas Tesla in tracking down a weaponized early version of a microwave.