Detective William Murdoch leaves Toronto for the Klondike Gold Rush, intent on a life beyond policing. While there he stumbles upon a murder investigation and soon realizes his days as a detective are not behind him.
Detective Murdoch must tread carefully when he pursues a Catholic suspect in the murder of an Alderman, killed during the attempted assassination of the city's Protestant Mayor.
When Detective Murdoch investigates a series of deaths linked to an exhibition of Egyptian antiquities, Constable Crabtree is convinced a mummy's curse is to blame.
While investigating an explosion, Detective Murdoch infiltrates an anarchist group lead by American labour organizer Emma Goldman.
When Elvira Cummings, a young opera singer, is poisoned during a rehearsal of La bohème, Detective Murdoch suspects the intended victim was Madame Rosa Hamilton, the diva who stormed off stage moments before her protégé collapsed.
Detective Murdoch suspects the ambitious inventor of an electric vehicle murdered an associate who stood in the way of his plans to compete with Henry Ford.
Detective Murdoch's investigation into the disappearance of a quiet librarian leads to a reunion with former love Anna Fulford and the discovery of a seamy underworld.
After saving his lover Anna from the Black Hand, Detective Murdoch bargains for her life. During his investigation into the murder of a shy librarian with a secret life, he encounters another young woman behaving seductively.
After a high stakes card game involving Dr. Grace ends with the death of a player, Murdoch is shocked to learn the true cost of their wagers is the opportunity to die.
After a ruthless inventor is killed at a convention, Murdoch's investigation is assisted by his idol, Alexander Graham Bell.
Detective Murdoch is taunted by a deranged criminal who leaves talking dolls with macabre personal messages at each crime scene.
Toronto's hockey championship fortunes rest on Murdoch's shoulders when he investigates the death of the team captain.
Murdoch investigates the claims of a man who says his time travels to the future provided him with information that allowed him to stop crimes, while the New Year's Eve Policeman's Ball offers exciting personal possibilities for the 20th century.