Frankie is excited and looks forward to re-bonding and taking care of Sue and Axl, who both have to stay home during Spring Break to recuperate from having their wisdom teeth removed. And since he's the only Heck child still living at home full time, Brick tries to lay down some new house rules with his siblings during their stay. Meanwhile, Mike becomes furious with brother Rusty after discovering that his ex-wife Marlene came up with the diaper business idea and may be entitled to all profits made from the endeavor.
After making some extra money from the diaper business, Mike surprises a rather unenthusiastic Heck family with a spring break vacation at Mammoth Cave, Kentucky. In the hopes of livening up what is perceived to be a lame vacation, Frankie suggests that the Donahues join them. While Mike visits all of the attractions on his own, Nancy asks a not-so-thrilled Frankie to speak with Sean to try and talk him into taking his MCATs; Axl enlists Brick to help him pick up women by playing "Jerk/No Jerk" - with Brick in the role of the "Jerk"; and Mike is anything but excited when an exuberant Sue reveals some news to him about her upcoming summer plans.
Sue develops a huge crush on one of her college professors and goes to extremes to get him to notice her, and Frankie and Mike agree to meet Brick's girlfriend Cindy's parents, who end up being just as quirky as their daughter.
Frankie is thrilled when Sue invites her for lunch at the college. But lunch becomes awkward when Sue brings her new boyfriend along - Jeremy, the school activist - and the two of them begin bombarding Frankie with everything she and the world, in general, are doing wrong. Meanwhile, Axl informs a very disappointed Mike that he wants to quit football, and Brick overly obsesses over filling out a satisfaction survey after ordering some graph paper online.
Frankie is excited to lay out and relax on her new backyard lanai - aka patio - that Mike and his workmates built for her. But peace and serenity become hard to come by when new neighbors, with three screaming kids, move in next door and make it next to impossible for Frankie to find some quiet time. Meanwhile, Brick questions Mike as to whether his workmates helped build the lanai because they are his friends, or because he's their boss; Sue and Lexie draw a winning number in the dorm lottery and score the perfect room but find it difficult to kick out its current occupants; and Axl and Hutch open up a grilled cheese food truck out of their Winnebago, with a reluctant Kenny as their chef.
After enduring year after year of botched Mother's Days, Frankie declares that the family gets to take a pass on doing anything at all for her this year. But after a man offers to buy Frankie's groceries at the market when she discovers that she forgot her wallet – and tells her to pay the kindly gesture forward – she decides to have the family pull each other's names out of a hat and do something nice for that person, which doesn't go as smoothly as planned.
Now that summer vacation has begun for Sue and Axl, and they are both back at home, Frankie and Mike attempt to set a curfew for them after they end up coming home from a party at 2 a.m. But after arguing that they don't have a curfew while away at college and won't abide by the rule, Frankie comes up with an idea that will clandestinely let her know where both of them are at all times. Meanwhile, as middle school graduation nears, Brick desperately tries to discover who he's up against for class valedictorian.
After almost forgetting that Brick's middle school graduation is only days away, Frankie goes on a mission to right a wrong when Brick discovers that the song he was supposed to sing at the ceremony has been cut. Meanwhile, Sue needs to be at Dollywood to begin her summer job on the same day as Brick's graduation, and Axl takes a job as a country club counselor and finds himself being mocked by a 10-year-old carbon copy of himself.
Frankie and Mike are excited to meet April – the love of Axl's life – but discover that love may indeed be blind when April reveals a quirky personality trait. Meanwhile, after getting bit by the acting bug while working at Dollywood over the summer, Sue wants to change her major to theater, and Brick is starting high school and making it his mission to try for a fresh start and not be considered one of the weird kids.
When a devastated Sue discovers that she has been kicked out of college because she forgot to renew her financial aid, Mike tries to come to her rescue and convince a tough college bursar to reinstate her. Meanwhile, having only taken oral liquid medication all of his life, a frustrated Frankie does everything in her power to teach Brick how to swallow a pill when he gets an ear infection; and Hutch becomes angry with Axl after he keeps driving the Winnebago without permission to Orson to visit new girlfriend April - leaving Hutch without any means of transportation to get to class.
As Halloween approaches, Frankie is taken aback when she discovers that, if the circumstances ever arose where she and Mike got divorced, the kids would all choose to live with Mike. Meanwhile, Sue tries everything in her power to get her room back from Brick, and having to be so nice around girlfriend April all of the time leads Axl to lash out at his family.
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