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Most Extreme Humans follows people from around the globe living with the world's rarest and most remarkable physical conditions. From a Filipino man whose hands have grown so large he wears wristwatches as rings, to Brazil, where the world's smallest married couple have a combined height under six feet, to a 19-year-old in India living with the ultra-rare condition known as "werewolf syndrome." This series examines what everyday life looks like when the world is not built with your body in mind.
Mahfuza and Nelly are living with Harlequin ichthyosis, one of the world's rarest and most severe skin conditions; Mahfuza prepares for her first boxing match; Nelly fully supports her friend but worries that the high risks may outweigh the rewards.
Summer has macromastia, a condition that causes her breasts to keep growing. With constant pain in her back and neck from breasts that are now a third of her overall body weight, Summer travels from Scotland to Los Angeles looking for answers.
Ecuadorian conjoined twins Jose Luis and Jose Armando leave their home and family to get advanced medical care for a chance at independence. Teenaged Thai conjoined twins Pin and Pan must navigate their ongoing differences they prepare for adulthood.
In Indonesia, Dimas dreams of becoming a martial arts warrior, but his family worries the training will harm his oddly bendy body; in Colombia, Herson's backward-bending knees are failing, and he questions his dream of proposing to his girlfriend.
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