When the hospital's power source is damaged, Vanessa and the survivors only have three hours of reserve power for the UV lights - the only thing keeping the vampires at bay. While Vanessa and Axel head into the ruins of Seattle to scavenge parts, the others are left to fight: against both vampires and amongst themselves.
Vanessa and Mohamad head into the vampire-controlled streets in search of Vanessa's daughter; Cynthia is found dead at the hospital, and Doc thinks her apparent suicide is actually a deliberate murder; Vanessa is captured by vampires.
Vanessa, now in the clutches of Julius and his vampire brood, is forced to demonstrate her powers; the refugees discover a serial killer among the residents, and plot to wrestle control from Axel.
Vanessa and Susan are chased by mutated feral vampires in the sewers, arriving back at the hospital only after a hostile takeover.
Vanessa and Axel lead the hospital's last stand against a siege by Julius and his vampire soldiers; Dmitri's arrival with his vampire "Death Squad" reveals a possible civil war brewing among the two vampire factions.
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