My 600-Lb. Life: Transformed

Christina's mother and husband enable her over-eating, and these relationships may strain under the extreme changes she has to make.

Bettie Jo is alarmingly obese but her husband has sabotaged her health, fearing that she'll leave him if she loses weight; after struggling to drop the pounds, Bettie Jo discovers that she's pregnant and has cancer.

Chay confronts the emotions that led him to 600 pounds at age 23, and tries to manage life's hurdles so he can lose enough weight to get the gender reassignment surgery he greatly desires.

Pauline must overcome a food addiction and unwillingness to take care of herself to make a lasting change, but a medical emergency may permanently derail her weight loss efforts.

At 39, Paula feels trapped by her 533-pound body, but losing the weight proves harder than she thought, even with the doctor's help.

Susan, at 37 and 600 pounds, will have to be stronger than ever to fight through two unforeseen medical challenges that threaten her weight loss goals.