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There is no Next Episode of NYPD Blue planned.
After Joey Salvo's murder, Bobby's on suspension and has not talked to Andy for a while. With the FBI and Diane pushing him, Bobby confronts Andy about his suspicions regarding Salvo's murder. When Andy convinces him he's not the shooter, they put together a plan to shake loose the man they think did the crime. In other news, a drug-crazed man is murdering perfect strangers because he thinks they are his enemies; Jill has a surprising new relationship; James and Greg are both going to be parents; and Bobby makes Diane an offer for life.
Bobby's back on the job, but things are a little uneasy between him and Andy until they work a bar shooting where a terminally ill prison guard holds the key to solving the case. Diane uses a suspect's sexism against him on a string of rape-assault cases. James and Gina get married.
Greg swings into action when Abby's lover is murdered during a break-in, tying the case to a disturbed figure from Abby's past. The rest of the squad tries to unravel the case of a young woman who was shot and then burnt beyond recognition.
As Andy ponders the lyrics to "Pop Goes the Weasel", he and Bobby must help a murder witness who has a perfect head for details but is otherwise out of her mind. After she gets kidnapped, Andy's hypocrisy gets a workout when he castigates ADA Leo Cohen for making a deal to get her back safely, leading Jill to give Leo some kind words. Greg and James find out an Indian man's brother is behind a series of cab robberies.
Sipowicz struggles to suppress his rage while investigating the rape of a little girl, coming face to face with a suspect who sends him way over the edge. Meanwhile, Simone is utterly distressed by the brutal depths to which a drug-addicted mother will go to support her habit, then disgusted with himself for solving the murder of a Korean grocer. And that murder, in a predominantly black neighborhood leaves his grieving son hostile toward everyone, including the detectives at the 15th Precinct.
Vince Gotelli returns to the 15th's lives when a sleazy bus driver comes under suspicion in the deaths of his wife and sick young son. Lt. Fancy gets a visit from an old friend, a musician dying of cancer who has information about a 20-year-old murder, and later reflects to the friend about his life and where it's going. A record company executive who nobody in his life could stand is beaten to death, but the investigation leads to an unlikely suspect.
Two young women who secretly worked as exotic dancers are raped and murdered, leaving Andy and Bobby to wade through a sea of scum before closing the case. An unreliable acquaintance of James' says that a man's estranged wife and her new lover are in danger from the cuckolded husband, leading the cops on a wild goose chase. Diane is angry when a snooty woman blames an accidental theft on her immigrant housekeeper, and closes the case before letting the woman know she will get an INS visit if she mistreats the worker again.
In a two parter, a young boy named Brian is reported missing by his controlling father and distraught mother. The father becomes the prime suspect but all of the evidence points to a mute, homeless man named Israel. Andy is unable to hold his temper in check and after Brian is found dead, asks Fancy to remove him from the case.
Andy later is left reading a Bible for answers after Israel commits suicide. Diane takes over because she's been sidelined as Greg's knowledge of Orthodox Judaism becomes useful while he and James track down the scumbags who robbed and murdered a Hasidic woman. While Diane tries to get the wife to tell what she knows about her husband, Bobby gets through the husband's defenses and he begins to start revealing terrible information. An insurance scam involving homeless amputees provides a ruse that lets the cops solve Brian's murder.
Andy's old friend Wally asks him for help because Wally's daughter Carla is in a weird relationship with a woman named Margo. Andy learns Carla is a piece of garbage and her boyfriend is worse, and comes after them when Margo is beaten to death, though it's Bobby who gets to the point fastest. Greg and James bust a junkie who says he's been dumping dead bodies and associated parts around the city for a corrupt cemetery owner. Bobby learns the true background story of PAA Naomi.
Diane's pregnancy is revealed to Bobby, but it leads to an ugly scene when she insists on a dangerous assignment that turns into a shootout and he yells at her about it in front of everyone. James' anger overtakes both his reserve and his back when he finds out a city official threw an OD victim into a dumpster. Noami tells Bobby she's been turned into the INS for being an illegal from Australia, but she will fight to stay in the U.S.
In the 100th episode of the series, an attractive woman is found dead in a valuable wooden box. Andy and Bobby link the crime to her stupid, worthless brother, but it takes a few bottles of Coca-Cola to get the whole story. Diane's pregnancy weighs on her mind when an unloving mother's louse of a boyfriend accidentally kills her son. Greg, James and Jill catch a murder at a car-repair shop that turns complicated when the family of the victim says they and God forgive the killer.
Greg's head is spinning when a man claims his identical twin is violent and threatening both himself and his girlfriend, and he tries to figure out if there is even another twin out there. A junkie is committing robberies at ATMs, and Jill's bonding with his mother may be the only way to bring him to justice. Andy gets medical news that he does not share with anyone, including Sylvia, and an attractive new PAA named Dolores arrives.
A teenager named Weaver is thrown to his death, but Fancy is more focused on his father's racial slurs than solving the case, eventually targeting Andy for doing his investigation objectively. After Bobby gets devastating personal news from Diane (lost of her child) and has to listen to them all day, he finally screams at them both to shut up. An African immigrant's wife is found hacked to death, and Jill figures out the buttons to push to find him and get him to confess.
A nurse is strangled and stabbed to death. Suspicion initially falls on a mental patient at the hospital she worked at, but Andy and Bobby later learn she was having an affair with a married uniform cop named Tommy Richardson, and try to prove he did the crime. Jill uses a trick involving a soda can to get a mute suspect to confess. Andy's doctor comes to the precinct to get him to face his bad health news, but Andy loses his temper and throws the guy out of the 15th.
Andy and Bobby continue to investigate Tommy Richardson, but none of their ideas work and the most Andy can do is warn Tommy to transfer out of the 15th. Two thugs beat up a student filmmaker and steal his camera, but Diane and Jill are worried the filmmaker will seek his own revenge. Greg gets an emergency call from Abby only to learn she's not in labor. And Andy is confronted & comforted by Sylvia after she gets the word about his health: he has prostate cancer.
A shooting at a health clinic turns out to be a love triangle involving a lonely wife, her angry boyfriend, and a white-knight guard whose desire to protect her leads to a shootout at the 15th. The rape of one woman and another's murder lead Andy and Bobby to a feud involving a crippled drug dealer who knows Andy from Andy's uglier days on the force. Andy tells Bobby about his health condition. Fancy is happy to do some police work when he takes a statement on the shooting case.
Tommy Richardson's wife, Laurie, stops by the station to pick up his time records after he transfers to another precinct, where she expresses to Simone and Russell about Tommy's behavior after she caught him in a phone conversation with another woman. Meanwhile, Medavoy and Kirkendall look into the death of a man who was shot and found in the bathtub of his former girlfriend. Also, Sylvia accompanies Sipowicz to the hospital for his latest CAT scan test which goes wrong and they decide to ignore Dr. Talbot's advice and go with the opinion of Dr. Mondzac.
James and Greg reveal that Gina and Abby have given birth. Andy undergoes his prostate surgery and suffers through the agonizing first steps in his recovery process. The rest of the squad catches the murder of an Army veteran who was in town with five buddies from his service days. The more the cops talk to them, the more they think they have uncovered a larger and more dangerous problem.
Andy is still in pain when he returns to work on a case involving the missing daughter of a crack addict. Andy clashes with ADA Cohen over an immunity plan and later has to use creativity when the girl is found dead. Sylvia shows up to help Andy as well as salvage a criminal case. Bobby learns an elderly tenant at his building is missing and speculation falls on Henry Coffield. Bobby does not think Henry's guilty and follows up on another lead when the elderly tenant's fate is revealed.
When the detectives are called to the scene of a murdered prostitute who is covered excessively with bodily fluid, a repulsed Medavoy employs a clever strategy to get the suspect's confession. Meanwhile, Simone and Sipowicz take pity on a misguided young man accused of killing a sleazy car dealer; and Sipowicz gets still more alarming news about his health.
Simone and Sipowicz help a frenzied A.D.A. Cohen, who suspects that a defense attorney may have been involved in the execution-style murder of a witness and her child. Medavoy and Martinez bust a slick con man who manufactures fake sports memorabilia; and both Simone and Sipowicz reach significant milestones in their romantic relationships.