Set against the vibrant backdrop of one of the world's hottest cities - Miami - private pathologist DR. BEAUMONT ROSEWOOD, JR. (Morris Chestnut, "Nurse Jackie," "The Best Man" franchise) must crack a case that hits close to home. As he begins his investigation, Detective ANNALISE VILLA (Jaina Lee Ortiz, "The After") gives him a run for his money as they cross paths and are forced to work together to help the Miami PD solve the case.
When an unexpected piece of evidence surfaces in the 305, Rosewood and Villa attempt to solve a serious crime involving a very well-off Miami man. Meanwhile, Rosewood struggles to balance a new romantic interest with the demands of his mother, and Villa runs into trouble on the job.
A series of mysterious deaths pulls Rosewood off the glamorous promenades of South Beach when a troubled young genius stands accused of murder, and the only one who believes in his innocence is Rosewood. He must contend with a colorful new adversary, escalating health problems and a burgeoning romantic relationship, while Villa's inability to connect with people hampers her own ability to investigate the case.
When Rosewood and Villa suspect a brilliant doctor has killed two of his patients, they must find a way to make their case with limited evidence. Meanwhile, Villa spars with Captain Hornstock when he discourages her from pursuing an uncertain case. Also, Rosewood receives an anonymous letter revealing something that could change his life forever.
Rosewood and Villa make it their mission to seek justice for a murder victim who is an ex-con with ties to a Little Haiti gang. Meanwhile, Villa struggles with dreams she's been having, and Rosewood deals with an unexpected turn in his relationship with Kat.
When Captain Hornstock becomes the prime suspect in his third ex-wife's murder, he turns to the only two people he can trust to prove his innocence, Rosewood and Villa, forcing them to repair their severely damaged relationship in hopes of clearing his name. Meanwhile, Shirley's revelations lead to emotional consequences for Rosewood and Pippy.
While testifying for the prosecution during a murder trial, Rosewood engages in a pathology chess match with the expert witness for the defense - his father (guest star Vondie Curtis-Hall). Then, when Donna and Beaumont Sr. make an unexpected announcement, it has unforeseen consequences.
Rosewood and Villa are thrust into the underbelly of the everglades when they team up with Hornstock's ex-partner-turned-bounty hunter, Floyd Butters, to catch a murderer. Meanwhile, Pippy is given the opportunity of a lifetime to launch her music career, and Villa tries to reconnect with her mom.
Amidst the glitz and glamour of Miami Fashion Week, there's a plot to kill one of the city's hottest new designers, who turns to Rosewood for help. As the case takes Rosewood and Villa from the catwalk to the perp walk, Rosewood learns of his shared past with the victim. When he enlists the aid of his best friend, Dr. Mike Boyce (guest star Taye Diggs), Rosewood unintentionally gives Villa the jolt she needs to get back into the dating pool. Potential love also is in the air for Donna, who tries her hand at online dating. Meanwhile, Pippy and TMI find their romance on the skids when Pippy discovers TMI has kept an important secret from her.
Rosewood and Villa dive into the hip Miami art scene to catch a serial killer who is on the cusp of creating a "masterpiece." When TMI's ex-fiancé, FBI Detective Heath Casablanca, joins the hunting party, he threatens to sabotage Pippy and TMI's relationship. Heath also butts heads with Hornstock, who stands to take over as police chief if he can catch the killer. Meanwhile, an impending lawsuit against Rosewood threatens the lifeline of Magic City Lab and forces Donna to take a long hard look at the way her son lives his life. Also, Rosewood tries to protect Villa from his best friend, Mike.
Picking up where the series left off after the fall finale, the search for the serial killer takes a very personal turn, as Rosewood and Villa must follow a trail of clues left for Rosie, before another victim falls prey. As things heat up between Villa and Mike (guest star Taye Diggs), Villa escapes by throwing herself deeper into the case, which inevitably pushes her closer to Rosewood. Meanwhile, Donna intervenes when Pippy decides to give TMI's absentee mother a piece of her mind. Plus, the Chief position is Hornstock's, if he is willing to pay a stiff price.
Hornstock forces Villa to pick a new partner, and she immediately clashes with the one assigned to her. After learning she cost Hornstock the job as Chief, Villa tries to make herself less of a liability, which reveals a surprising pattern in her life. Meanwhile, the death of a victim forces Pippy to offer her assistance in the investigation and to revisit her past. The case stirs up old wounds for the entire Rosewood family and creates new ones for her and TMI. Meanwhile, Rosewood's slight health scare leads him in search of a new cardiologist.
Rosewood's partnership with Villa faces an uncertain future when she's paired with a recent transfer to the East Miami PD, with whom she shares a past. As Villa and her new partner investigate the death of a suburban dentist who ran a yuppie drug ring, Rosewood can't shake the feeling that his "replacement" knows more about the victim's narcotics business than he's letting on. Meanwhile, a new medical examiner, Dr. Anita Eubanks (guest star Sherri Shepherd), is brought in to help with the investigation and Hornstock's insecurities hinder his ability to handle the public relations side of the case, forcing him to turn to an unlikely source for help.
Rosie insists on celebrating his and Villa's nine-and-a-half month anniversary as partners, which lands them in the middle of a case involving none other than Julius "Joo-Joo" Beeman, their confidential informant. But, this time, Joo-Joo is the prime suspect. As Rosie and Villa work to uncover the truth, even if it means putting Joo-Joo away for life, they discover a whole new side of him they never saw coming. Meanwhile, Villa's choice for her new home has Rosie worried about the new path she's on, Pippy and TMI struggle to balance old friends and family, and Hornstock has trouble reading signals from the new, badass, female chief of police.
While at an out-of-town forensic pathology convention, Rosewood unintentionally reveals the blueprint to commit the perfect murder during a speech to the convention attendees. Tormented, and armed only with a hunch, Rosewood enlists Villa to help solve the crime, and while investigating undercover, sparks fly unexpectedly between them. Hornstock and Floyd Butters are called upon for extra help. Meanwhile, Pippy and TMI have locked themselves in the lab overnight to help with the investigation and TMI receives an unexpected visit from her estranged father.
Rosewood investigates the suspicious death of a man with medical issues similar to his own, which forces him to slightly adjust the tint on his Rosie-colored lenses and confront his own mortality. Also adding to his stress, he finds himself trapped between Donna and his girlfriend/cardiologist, Dr. Erica Kincaid (guest star Joy Bryant), and their dueling opinions over what's best for Rosewood - medically and personally. Meanwhile, Hornstock enlists the help of Villa as he attempts to reconnect with one of the witnesses linked to the case..his estranged teenage daughter, Sophie.
Rosewood and Villa investigate the murder of a telenovela star, holding a mirror up to their own relationship as they explore a world of off-screen soap and intrigue. Meanwhile, Erica (guest star Joy Bryant) strong-arms her way into Rosewood's life, much to Donna's chagrin. Then, Rosewood's precious GTO is stolen, and Villa reconnects with her mother, Daisie.
When two bodies and lot of cash wash up on the shore of Miami Beach, Rosewood and Villa are forced to work with a rival private pathologist who threatens Rosewood's contract with the East Miami Police Department. Meanwhile, Daisie moves in with Villa and oversteps her boundaries, while TMI tries to keep up with Pippy and Cassie.
Despite each being at the top of their fields, Villa and Rosewood are stumped when a local musician and king of catchy jingles suddenly keels over in his studio with no discernable cause of death. Meanwhile, Donna enlists Mitchie to investigate Erica's "missing year".
When a patient of Erica Kincaid's dies on the table, Rosewood steps in to help solve what turns out to be the murder of an undercover ATF agent. But when Villa connects with a cold case detective, it turns out this case has more angles than they ever imagined.
An old flame of Rosewood's shakes up Rosewood's life when she returns to enlist his help in finding a wealthy patient of hers who's disappeared. But when the man's body surfaces, triggering a murder investigation, things are not what they appear to be. As the bizarre turns of this case come to a head, so does Rosewood's personal life as he is pushed to make decisions regarding all the women in his world.
Rosie and Villa find themselves caught in the middle of an explosive investigation that makes them question whether justice really is blind. Meanwhile, as the decks are cleared for Rosie and Villa to finally act on their feelings, Rosie stumbles on some information that forces him to embark on his own private investigation behind Villa's back. What he finds could change their relationship forever. Also, Pippy and TMI are moving closer to their wedding day, Donna's behavior leads Rosewood and Pippy to suspect she has a new man in her life and an error from Hornstock's past comes back to haunt him.