While Dean brings Mary up to speed on what has happened in the 30 years since she's died, Sam faces tortured at the hands of the Men of Letters. Meanwhile, Crowley tries to track down a weakened Lucifer, who is hopping from body to body.
Dean and Castiel continue their efforts to find Sam, and Mary insists on accompanying them. Meanwhile, Castiel recruits Rowena in his attempts to send Lucifer back to the cage.
When a crying baby leads to death in a mysterious abandoned house, Mary, Sam and Dean decide to investigate. Meanwhile, Castiel's hunt for Lucifer leads him, begrudgingly, to partner up with Crowley.
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