When an American college student working in Johannesburg is killed and his brother goes missing, the International Response Team suspects a gang could be behind both. Jack works the case with Lieutenant Ananda Doshi (Bahni Tupin), a profiler he's worked with before who has an unorthodox style of investigation.
When American victims are found in different locations throughout Cuba, the International Response Team heads to the island nation to search for possible spree killers.
The IRT heads to Pamplona, Spain, for the running of the bulls, where the ears of a missing American tourist are found.
When the daughter of an American family visiting Haiti to adopt a child is kidnapped, the International Response Team travels to the island nation to try to find her. Also, Jack (Gary Sinise) and his wife, Karen (guest star Sherry Stringfield), prepare to send their daughter to college.
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