Garrett and his unit travel to Thailand when three American volunteers go missing during a trek to Bangkok. Once there, former colleague Clara Seger, a cultural anthropologist, helps them rush to gather evidence leading to the UnSub before a storm threatens to wash it away,
An American attending a festival in Mumbai wakes up missing a kidney and his friend gone. The investigation leads Garrett and his team to suspect the UnSub is up to more than just trading organs on the Black Market.
The team heads to Cairo to uncover who is behind a gas attack there on an Egyptian-American and the disappearance of the victim's friend.
The team travels to Japan to assist local law enforcement in investigating homicides made to look like suicides. Meanwhile, Mae encourages Clara to get out and enjoy herself.
The International Response Team heads to Paris to search for an UnSub targeting Americans who live there.
The International Response Team heads to Belize to search for a couple who disappears while on their honeymoon in what appears to be a targeted abduction.
The International Response Team travels to Morocco when a retired couple from Idaho is kidnapped while visiting the country on a cruise.
When a woman vacationing in Mexico with her family is the victim of foul play, the International Response Team investigates her husband as the prime suspect when he flees.
When an American girl runs away to meet her boyfriend in Turkey, the International Response team suspects she was tricked by someone posing as him.
When an American college student working in Johannesburg is killed and his brother goes missing, the International Response Team suspects a gang could be behind both. Jack works the case with Lieutenant Ananda Doshi (Bahni Tupin), a profiler he's worked with before who has an unorthodox style of investigation.
When American victims are found in different locations throughout Cuba, the International Response Team heads to the island nation to search for possible spree killers.
The IRT heads to Pamplona, Spain, for the running of the bulls, where the ears of a missing American tourist are found.
When the daughter of an American family visiting Haiti to adopt a child is kidnapped, the International Response Team travels to the island nation to try to find her. Also, Jack (Gary Sinise) and his wife, Karen (guest star Sherry Stringfield), prepare to send their daughter to college.