Roger (Seth MacFarlane) opens a crooner's bar in the Smith family's attic and recruits Hayley (Rachael MacFarlane) as his main entertainer. Soon, all of Langley Falls becomes enthralled by her singing voice - including Roger, who takes his crush on Hayley a bit too far. Meanwhile, Stan tries to prove his manhood by negotiating a good deal on a new car.
The Smith family's tropical vacation turns out to be anything but relaxing when Stan is assigned a mission to kill the activities director at their resort, whom his boss at the CIA insists is an ex-war criminal. Meanwhile, Hayley (Rachael MacFarlane) and Jeff (Jeff Fischer) try to rekindle their fading romance, while Roger, as his latest persona, Abigail Lemonparty, falls for an older gentleman.
Francine fears that she and Stan (Seth MacFarlane) are growing apart because he spends so much time hanging out with his buddies at the "CIA Chill House." Meanwhile, Steve and his friends are recruited to join a boy band and make a music video.
Stan (Seth MacFarlane) invites his mother (guest voice Swoosie Kurtz) to come live with the family after Stan's stepfather dies, and tensions rise when Roger (Seth MacFarlane) is forced to share his attic with her. But Roger and Stan's mom quickly fall in love and get married, and Stan is forced to deal with Roger as his new stepdad. Meanwhile, Steve (Scott Grimes) and his friends discover a mysterious plane crash while on a bike ride and come across a long-lost script of a "Fast and Furious" movie that they are determined to get made.
Stan decides that Snot isn't cool enough to be Steve's best friend. So he attempts to separate them by staging a shooting at an ice cream parlor, of which Snot is the only witness and is then placed in the CIA Witness Protection program. Meanwhile, Roger hires Jeff to clean his attic for extra cash, but keeps robbing him every time he goes back downstairs.
The Smith family's regular babysitter, Lindsay (guest voice Alison Brie), breaks her leg in a soccer match. So Stan and Francine are forced to leave Steve with Hayley, despite her track record of being extremely irresponsible. When Hayley teases Steve about being a goody-two-shoes, Steve is determined to prove her wrong and sneaks out of the house to go to a party with the cool kids.
A Langley Falls talk show outs Francine as "Baby Franny," the toddler who was once rescued from a well by a heroic fireman (guest voice Wil Forte). Then, on the anniversary of her rescue, she falls down the well again and makes a shocking discovery. Meanwhile, Stan and Roger have an entrepreneurial "eureka!" moment when they think of the world's next game-changing business opportunity - male stripper shoes.
Francine encourages the family to give up their various vices, but they all get drunk at Roger's Mardi Gras party and enter into a harrowing pact with Bullock. Meanwhile, a pastie is left in the attic, Cinderella-style, and Roger sets out to find the "perfect bosom" on which to place it.
Francine tries to teach Roger the value of hard work after his character "Twill Ongenbone" fakes a degree in archaeology, but she quickly regrets her decision. Meanwhile, Steve asks Stan questions about Stan's past for a school project, but is shocked by what he hears.
In a tribute to and send-up of the Pulitzer Prize-winning play, "August: Osage County," a dark secret is revealed about the Smith family's past when Francine invites Stan's incarcerated dad, Jack, to Stan's birthday party. Also in this spoof, Roger plays Edna, a maid who nurses Bullock and Hayley's love child. But when Edna falls in love with Bullock, it could mean dire consequences for the kid.
Roger (Seth MacFarlane) announces that "Max Jets," a character of Roger's who enjoys showering the Smith family with money, is soon getting out of prison. But a wrench is thrown in the system when Max falls in love with Gina (Michelle Monaghan), a gold-digging waitress who threatens the family's inheritance.
Roger pretends to be Jeff's imaginary friend, so he can freely roam naked around the house with no disguise. But when big-mouth Jeff figures out that Roger is an alien, Stan issues an ultimatum: either Roger or Jeff must be killed immediately. Meanwhile, Steve becomes insecure about the shape of his rear end.
In Part 2 of "The Tearjerker Saga," a "James Bond" parody, Stan and his wife, Sexpun Tocome's honeymoon is brutally interrupted when Black Villain (guest voice Kevin Michael Richardson) fatally shoots Sexpun. Determined to get his revenge, Stan teams up with former nemesis The Tearjerker to track down Black Villain and put a stop to his evil plan to melt the arctic glaciers.
Francine discovers Steve's special talent that will help him get into a great school: spelling. But when she fears that Steve is being distracted by Hiko's sister, Akiko, she takes drastic measures to ensure victory at the Pearl Bailey High School Spelling Bee. Meanwhile, Stan and Roger want Hayley to line-judge their badminton game, but she's still devastated over Jeff, so they decide to push her through the five stages of grief as quickly as possible.
Francine does all she can to make Stan take on a different mission. And when he does, she learns that her missionary man is all she really needs. Then, Hayley tries to get back into the dating scene with disastrous results, and reluctantly submits to Snot's (Curtis Armstrong) advance, agreeing to a dinner date.
Francine tries to mold Stan into her ideal husband when he gets amnesia after falling off an arcade game during a CIA operation to capture the "real" Osama bin Laden (who, apparently, has been managing a "Dave and Buster's" restaurant in Florida). Meanwhile, Roger lets Steve join his paper route to earn some extra money, but Steve is drawn into the corrupt side of the business.
Stan is shocked when Agent Crisp (guest voice Phil LaMarr) from CIA Internal Affairs tells him that Deputy Director Bullock (guest voice Patrick Stewart) is showing early signs of dementia and must have his memory erased. Meanwhile, Steve runs into a bully at school, so Roger hires an old friend - Stelio Kontos - to take care of the problem.
In the special 150th episode, the series travels to the slave spaceship that abducted Jeff (Jeff Fischer) -- with Roger's (Seth MacFarlane) help - after Jeff discovered his secret (hint: Roger is an alien). To find his way home, Jeff must first prove to the evil Emperor Zing (guest voice Michael McKean) that he was always in love with Hayley (Rachael MacFarlane).
Klaus discovers his original human body, but Stan refuses to help him switch back. So, Klaus steals Stan's body and Stan becomes the fish. Meanwhile, Roger turns the attic into a gym, and tries to pressure Steve into a long-term membership.