The shinobi under Madara's Infinite Tsukuyomi continue to slumber and have pleasant dreams. Meanwhile, Naruto and the others have escaped the genjutsu, thanks to Sasuke's protective Susano'o. As Sasuke starts remembering the death of Itachi, his Sharingan starts to resonate and show him the truth that Itachi never spoke a word of.
Having experienced the Great Ninja War as a young child, Itachi constantly questions the meaning the life and death, distancing him from other children his age. Soon after entering the Academy, Itachi exhibits his genius and finds himself at the top of his class.
Upon graduating from the Academy, Itachi becomes a genin and joins a team that includes Tenma, Shinko, and their Jonin Leader, Minazuki Sensei. They accept a mission from Granny Cat to look for a missing feline who's a skilled Ninja Cat!
Itachi accompanies his friend Shisui on a three-part training exercise. The two come across a battle between the Hokage's ANBU and the Foundation. Itachi is confused by their motives and can't discern which side is right or wrong. But Shisui is unwavering in his determination to stop the fighting.
Itachi joins the ANBU and is quickly promoted to captain. But he must report directly to Danzo, and is placed as a double agent to observe the Uchiha clan, who are in the midst of planning a coup d'état. With dissatisfaction rising within the clan, the Uchiha ultimately decide to carry out their revolt, and the fateful night approaches.
Itachi becomes a rogue ninja and joins the Akatsuki. He is welcomed and introduced by Pain and Orochimaru as the ex-Leaf ANBU and the man who massacred his entire clan. Itachi is paired up with a man named Juzo, and their first job together is to fulfill an assassination request in the Land of Water.
Itachi is partnered with Kisame and begins his missions as a member of the Akatsuki. The duo succeeds in recruiting Deidara, so Pain assigns the newly formed team of Deidara and Sasori to hunt down the deserter Orochimaru. Meanwhile, intel comes in about an immortal killer, so Itachi, Konan and Kakuzu head out to the Land of Steam.
Itachi confronts Sasuke, who for years bore the shame and anger that Itachi brought upon their clan. The truth behind Itachi's story comes to light. Back on the battlefield of the Fourth Great Ninja War, Naruto and the others fight Madara, and just as he is declaring his victory, something unexpected occurs...